server {
    listen 127.0.0.1:80 default_server;
    root /;
    charset utf-8;
    client_max_body_size 128M;

    location / {
            root   /usr/local/etc/nginx/html;
            index  index.php index.html index.htm;
    }

    location = /favicon.ico { access_log off; log_not_found off; }
    location = /robots.txt  { access_log off; log_not_found off; }

    access_log off;
    error_log "/Users/youkaili/.config/valet/Log/nginx-error.log";

    error_page 404 "/Users/youkaili/.composer/vendor/laravel/valet/server.php";

    location ~ \.php$ {
            root           /usr/local/etc/nginx/html;
            fastcgi_pass   unix:/Users/youkaili/.config/valet/valet.sock; 
            fastcgi_index  index.php;
            fastcgi_param  SCRIPT_FILENAME  $document_root$fastcgi_script_name;
            include        fastcgi_params;
    }
}

主要就是配置fastcgi_pass php-fpm的位置在php-fpm.conf查询，如果没有去php.conf查找