Dim bigNumber As BigInteger = BigInteger.Pow(2, 63) - BigInteger.One
Dim uNumber As ULong = CULng(Int64.MaxValue And CULng(&h7FFFFFFFFFFFFFFF))
If uNumber <> bigNumber Then
   ' Do something...
End If

Dim number1 As BigInteger = 945834723
Dim number2 As BigInteger = 345145625
Dim number3 As BigInteger = 945834723 
Console.WriteLine(number1 <> number2)                  ' Displays True
Console.WriteLine(number1 <> number3)                  ' Displays False

Dim bigNumber As BigInteger = BigInteger.Pow(2, 63) - BigInteger.One
Dim uNumber As ULong = CULng(Int64.MaxValue And CULng(&h7FFFFFFFFFFFFFFF))
If bigNumber <> uNumber Then
   ' Do something...
End If

Dim bigNumber As BigInteger = BigInteger.Pow(2, 63)
Dim number As Long = Int64.MaxValue
If number <> bigNumber Then
   ' Do something...
End If

Dim bigNumber As BigInteger = BigInteger.Pow(2, 63)
Dim number As Long = Int64.MaxValue
If bigNumber <> number Then
   ' Do something...
End If