The other solutions use innerHTML, which won't always work in XHTML. They also only clear document.body (anything in the <head> is still present). Here is a solution that uses the DOM:
var frame = document.getElementById("myFrame"),
frameDoc = frame.contentDocument || frame.contentWindow.document;
frameDoc.removeChild(frameDoc.documentElement);
This solution uses innerHTML:
var frame = document.getElementById("myFrame"),
frameDoc = frame.contentDocument || frame.contentWindow.document;
frameDoc.documentElement.innerHTML = "";
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